- Title
- The renin-angiotensin system from conception to old age: the good, the bad and the ugly
- Creator
- Lumbers, Eugenie R.; Pringle, Kirsty G.; Wang, Yu; Gibson, Karen J.
- Relation
- Clinical and Experimental Pharmacology & Physiology Vol. 40, Issue 11, p. 743-752
- Publisher Link
- http://dx.doi.org/10.1111/1440-1681.12098
- Publisher
- Wiley-Blackwell Publishing Asia
- Resource Type
- journal article
- Date
- 2013
- Description
- The renin–angiotensin system (RAS) plays a critical role in placentation and nephrogenesis. Failure to thrive during intrauterine life, possibly related to placental dysfunction and impaired expression of the renal RAS, as well as prematurity, results in smaller kidneys at birth and reduced nephron number. The remaining nephrons are therefore hyperfiltering from birth. Hyperfiltration, infections and Type 2 diabetes cause glomerular and tubular fibrosis, leading to further reductions in nephron number. The intrarenal RAS plays a key role in promoting tubulointerstitial fibrosis. Low birth weight and a high incidence of preterm birth program Indigenous children for early onset renal disease in adult life. Indigenous Australians have 404 000 fewer nephrons than non-Indigenous Australians. This, coupled with the high incidence of infectious diseases (particularly acute post-streptococcal glomerulonephritis) and the increasing prevalence of Type 2 diabetes, explains why end-stage renal disease is of epidemic proportions in Indigenous Australians. The existence of RAS gene polymorphisms and inflammatory cytokines may further potentiate susceptibility to renal disease in Indigenous Australians.
- Subject
- chronic kidney disease; indigenous Australians; nephrogenesis; placentation; renin–angiotensin–aldosterone system
- Identifier
- http://hdl.handle.net/1959.13/1059476
- Identifier
- uon:16614
- Identifier
- ISSN:1440-1681
- Rights
- This is the accepted version of the following article: Lumbers, Eugenie R.; Pringle, Kirsty G.; Wang, Yu; Gibson, Karen J. " The renin-angiotensin system from conception to old age: the good, the bad and the ugly ". Originally published in Clinical and Experimental Pharmacology & Physiology Vol. 40, Issue 11, p. 743-752 (2013), which has been published in final form at http://dx.doi.org/10.1111/1440-1681.12098
- Language
- eng
- Full Text
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